The Dolcera Blog

The discovery of RNA interference (RNAi) is one of the transforming events in biology. Gene silencing agents such as small interfering RNA (siRNA), micro RNA (miRNA) and small synthetic oligo-nucleotides (DNA, RNA or DNA-RNA complex) lead to target specific RNAi. We aim at building a one-stop comprehensive database of RNAi agents patented or described in scientific literature.Dolcera has provision to customize the database against the target gene suiting client’s requirement. Till now, RNAi agents against some of the important cancer target genes are updated to the database and the trial access is available on request. These genes include bcl2, myc (c-myc, n-myc), ras (k-ras, h-ras, n-ras), VEGF, STAT3 etc. RNAi agents can be extracted and added to the database based on client’s interest.

Dolcera RNAi database can prove helpful:

• For scientific community: RNAi agent sequences aligned to target genes, extensive experimental data and comparison matrix of data from different patents with same focus.  
• For patent attorneys: Competitor watch, assignee vs. number of publications graphs, timeline based on application and publication dates.
• For venture capitalists/ Investors: Patent ranking based on disclosed information, data useful for decision making.

Salient features of the database:

1. Interactive maps of taxonomy: 4 levels of in depth classification of patents and scientific literature allow both “bird’s-eye view” and “in-depth views” of technologies.
2. Patent and non patent dashboard: Grouping specific elements into more general categories is conceptually easier and cleaner than entertaining hundreds of specific elements separately. Dolcera dashboard has a friendly user interface. It groups the patents according to the taxonomy, patent numbers, publications and application dates at the click of a button.
3. Sequence Dashboard: The tool not only aligns all patented/ non patented siRNA/ miRNA sequences to the target gene but allow user to see the sequence related information on a simple click of the mouse.
4. Experimental matrix: Experimental data be it quantitative (eg. % inhibition of target mRNA expression) or qualitative (eg. gel blots) are compared amongst patent document with similar focuses. This allows users to compare literature with same focus. The ranking of documents can also be done based on scoring matrices, which allows user to read the most relevant patent first.

 For database related inquiries or free demo call us at, Phone: +1-650-269-7952 (US) and  +91-40-6451-0832 (India). You can also email us at info@dolcera.com

To read more about RNAi database click here

To visit Dolcera’s website and to explore more patent/ IP related services click here

Tweet This Post  Delicious This Post  Digg This Post